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The  aim was to assess the  diagnostic value of  99mTc-Tektrotyd scintigraphy (TCT) and positron emission tomography/computed tomography using F-18 fluorodeoxyglucose (18F-FDG PET/CT) in the detection andfollow-up of neuroendocrine tumors (NETs), and their predictive value fordisease progression.    Material and methods  In this retrospective cohort, TCT and 18F-FDG PET/CTwere performed in 90 patients (37 men, 53 women, mean age 52.7 ±15.1), withNET. Correlation of Ki67 and tumor grade versus Krenning score and SUVmaxwas assessed, Kaplan-Meier analysis was used for progression-free survival(PFS), and Cox regression analysis was performed to identify the associationbetween progression-related factors and PFS.    Results  Out of 90, true positive TCT was detected in 56 (62.2%) patients, truenegative in 19 (21.1%), false positive in 4 (4.4%), false negative in 11 (12.2%),while 18F-FDG PET/CT was true positive in 69 (76.7%) patients, true negative in10 (11.1%), false positive in 5 (5.5%), false negative in 6 (6.7%). Mean 18F-FDGPET/CT SUVmax was 6.8 ±6.2. Diagnostic sensitivity of TCT was 83.6%, specificity 82.6%, accuracy 83.3% vs. 18F-FDG PET/CT sensitivity was 92.0%, specificity66.7%, accuracy 87.8%. A significant correlation between Ki67 and SUVmax wasfound in positive 18F-FDG PET/CT findings, unlike the correlation between Ki67and Krenning score. Median PFS was 25 months (95% CI: 18.2–31.8), in 18F-FDGPET/CT positive patients 23 months (95% CI: 16.3–29.7) and 18F-FDG PET/CT negative 26 months (p = 0.279). Progression-free survival predictors were SUVmaxand Krenning score.    Conclusions  In our study, TCT and 18F-FDG PET/CT have high diagnostic accuracy in detection of NET. Higher Krenning score on TCT and SUVmax in positive 18F-FDG PET/CT findings are predictors of disease progression. 99mTc-Tektrotyd scintigraphy and 18F-FDG PET/CT can be useful complementary toolsin management of patients with NETs and in predicting patients’ outcome.

Diagnostic and prognostic value of 99mTc-Tektrotyd scintigraphy and 18F-FDG PET/CT in a single-center cohort of neuroendocrine tumors