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we also investigated the prognostic correlation between the expression level of lncRNA HOTAIR in tumor tissues and peripheral blood of patients with advanced HCC and sunitinib monotherapy.    Material and methods  A total of 60 patients with advanced HCC who received sunitinib monotherapy and another 60 healthy individuals who were examined at the physical examination center during the same period were included in the study. Real-time quantitative PCR (RT-QPCR) was used to determine the relative expression of lncRNA HOTAIR in tumor tissue, adjacent tissue and peripheral blood of HCC patients as well as peripheral blood of healthy controls.    Results  Patients with low lncRNA HOTAIR expression in tumor tissues harbored significantly longer OS (13.4 vs. 9.5, P &lt;0.001) and PFS (8.4 vs6.2, P &lt;0.001) compared to those with high expression. Consistently, patients with low lncRNA HOTAIR expression in peripheral blood had significantly prolonged OS (12.8 vs9.1, P&lt;0.001) and PFS (8.9 vs6.4, P&lt;0.001) compared to those with high expression.Cox regression analysis indicated that the expression level of lncRNA HOTAIR in tumor tissue and peripheral blood was an independent predictive factor of OS and PFS in patients with advanced HCC treated by sunitinib.    Conclusions  The expression of lncRNA HOTAIR was up-regulated in tumor tissue and peripheral blood in patients with advanced HCC. In addition, the expression level of lncRNA HOTAIR was one of the indicator in predicting the effectiveness of sunitinib therapy.

The expression of long non-coding RNA HOTAIR in advanced hepatocellular carcinoma and the prognostic correlation of it with sunitinib therapy