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The transient receptor potential (TRP) channel, so named after the role they play in Drosophila phototransduction, takes a prominent position among these sensors and transducers in the digestive system. However, the roles of TRP channels in digestive function are incompletely understood. Changes in TRP channel expression or function are associated with a variety of diseases. The aim of this study was to analyze the expression of TRPC5 and TRPC6 by immunohistochemistry in the pyloric muscle in children with infantile hypertrophic pyloric stenosis (IHPS). Material and methods: Fifty-three muscle biopsies were obtained at the time of pyloromyotomy. The control group consisted of 10 children. Specimens were evaluated by routine histopathological methods and by immunohistochemistry using monoclonal mouse anti-TRPC5 or -TRPC6 antibodies. Cells showing positive reaction were counted in five random 200× high-power fields. Results: Immunohistochemical studies showed higher expression of both receptors in the muscularis propria and in the ganglia in children with infantile hypertrophic pyloric stenosis compared with the control group. The result for TRPC5 was statistically significant. Conclusions: These results show a local increase in the expression of TRPC5 and TRPC6 in the hypertrophic pyloric muscle in children with infantile hypertrophic pyloric stenosis, which may have implications for the pathogenesis of the disease.

Study of expression of two transient receptor potential (TRP) channels, TRPC5 and TRPC6, in children with infantile hypertrophic pyloric stenosis