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This study seeks to assess the effect of ethanol extract of Tridax procumbens (linn.) (EETP), a common procumbent plant with several potential therapeutic values, on sodium arsenite-induced toxicities in male wistar rats. Thirty five (35) male wistar rats divided into seven groups of five (5) each, were used. Rats in the pre-treatment, post-treatment and co-administration groups received 200mg/Kg body weight of EETP. Sodium arsente treated groups received 1/10 of LD50 i.e. 2.5mg/Kg sodium arsenite (SA) both in the cotreated groups and SA alone groups on day 1 and day 14, respectively. Liver enzymes, Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Gamma glutamate transferase (GGT), and Alkaline Phosphatase (ALP) and other biochemical parameters (Total Bilirubin, Total Protein, Albumin. Total Cholesterol, and Urea) were measured in tissue homogenate to evaluate toxicity in the induced animal model. Nephrotoxicity was assessed using serum creatinine level, while micronucleated polychromatic erythrocytes (mPCE) assessment was carried out for the genotoxicity testing. Statistical analysis using ANOVA and Dunnett’s post hoc test was done for all parameters measured. Percentage weight gain was significantly decreased (p<0.05) in the EETP+SA co-treated groups. There was a significant decrease (p<0.05) in GGT, AST, and ALT activities in the EETP+SA co-treatment groups when compared with the sodium arsenite-induced groups, in a treatment mode dependent manner with the pre-treatment group

Assessment of the Effect of Ethanol Extract of Tridax Procumbens (linn.) on Sodium Arsenite-induced Toxicities in Male Wistar Rats