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Severe clinical manifestations of asthma have been associated with menstrual cycle. Possible complication of asthma was reported to be infertility. White yam commonly used as food in SouthWest in Nigeria contains antioxidants and phytoestrogen. Aim and Objective: This work was designed to determine the bioactivities of two weeks white yam (Dioscorea rotundata) diet in asthmatic female students in relationship with mentrual cycle using luteinizing hormone, follicle-stimulating hormone, glutathione peroxidase and superoxide dismutase. Thirty nine asthmatic female students of Achievers University, Owo – Nigeria aged 19 – 31 years on 28 days regular menstrual cycle were recruited through the University’s health centre. Out of the thirty nine asthmatic female students 9 could not tolerate yam and green leafy vegetables for two weeks as a result of diarrhea, fourteen (14) were studied as test subjects fed yam and green leafy vegetables for the first two weeks of their 28 days regular menstrual cycle while the rest 16 asthmatic female students were studied as control subjects without yam and green leafy vegetables for the first two weeks of their 28 days regular menstrual cycle. Plasma level of Luteinizing hormone (LH), follicle-stimulating hormone (FSH), glutathione peroxidase (GPx) and superoxide dismutase (SOD) were determined biochemically by spectrophotometry and ELISA. The results obtained showed a significant reduction in the value of plasma GPx and SOD in asthmatic control students not fed on white yam at the mid cycle and also at the end of the third week of their menstrual cycle (p<0.05). This work also revealed a significantly higher plasma value of LH in the test after a 2 weeks of exclusive yam and vegetable meal than the control asthmatic female students at the end of 2 weeks of their menstrual cycle without yam and vegetable meal (p<0.05). Conclusion: White yam and green leafy vegetable supplement could reduce clinical manifestations and complications of asthma in asthmatic female students.

american journal of biomedical sciences

Bioactivities of Two Weeks White Yam (Dioscorea rotundata) Diet in Asthmatic Female Students in Relationship with Menstrual Cycle Using Luteinizing Hormone, Follicle-Stimulating Hormone, Glutathione Peroxidase and Superoxide Dismutase