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Availability of an acceptable animal model, which closely mimics human clinical situations in terms of receptors and route of entry, is of utmost importance to study host parasite interaction. In the present study, Swiss Webster (LACA) strain of female mice was chosen for induction of chronic renal inflammation by planktonic as well as biofilm cells of Pseudomonas aeruginosa. Bacterial inoculum was instilled thrice intrauretherally with the help of catheter. Both the cell forms were able to induce chronic renal inflammation in the experimental animals. However, severity of lesions induced by four day old biofilm cells was more as compared to planktonic cells. The chronic pyelonephritis model holds great promise for understanding the biology and pathogenesis of P. aeruginosa induced urinary tract infections as well as in development of effective preventive strategies.

Experimental Non-obstructive Chronic Renal Infection Model with Planktonic and Biofilm Cells of Pseudomonas Aeruginosa