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Obesity is a definite risk factor of Barrett’s esophagus (BE) and is associated with circulating levels of adipokines and inflammatory cytokines. Several studies suggested the association between BE and inflammatory cytokines or adipokines, but, their association is controversial.  Recently, Garcia et al1 performed the case-control study to investigate the relationship of BE with inflammatory cytokines and adipokines. The study included 141 patients with BE and 139 controls who underwent screening colonoscopy and esophagogastroduodenoscopy. They evaluated the association between BE and circulating levels of adipokines and cytokines (IL-1β, IL-6, IL-8, IL-10 and IL-12p70; tumor necrosis factor-α; and interferon-γ). BE had a positive association with high circulating level of IL-12p70, IL-8 and leptin, but had no association with IL-6. BE had a negative association with IL-10 and IL-1β. There were no differences between cases and controls in levels of interferon-γ, tumor necrosis factor-α, adiponectin or insulin.

Circulating Inflammatory Cytokines Are Associated With the Risk of Barrett’s Esophagus in Western Persons