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Fig. 1. Abdominal computed tomography showed a hepatomegaly and hepatosteatosis. REFERENCES 1. Baxter EJ, Scott LM, Campbell PJ, et al. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 2005;365:1054-61. 2. Scott LM. The JAK2 exon 12 mutations: a comprehensive review. Am J Hematol 2011;86:668-76. 3. Darwish Murad S, Plessier A, Hernandez-Guerra M, et al. Etiology, management, and outcome of the Budd-Chiari syndrome. Ann Intern Med 2009;151:167-75. 4. Milosevic Feenstra JD, Nivarthi H, Gisslinger H, et al. Wholeexome sequencing identifies novel MPL and JAK2 mutations in triple-negative myeloproliferative neoplasms. Blood 2016;127: 325-32. 5. Alghasham N, Alnouri Y, Abalkhail H, Khalil S. Detection of mutations in JAK2 exons 12-15 by Sanger sequencing. Int J Lab Hematol 2016;38:34-41.

Is N-acetylcysteine infusion an effective treatment option in L-asparaginase associated hepatotoxicity?