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TO THE EDITOR: Translocations involving chromosome 7 rarely occur in AML and to date, nine cases with t(7;21) (p22;q22) involving ubiquitin specific peptidase 42 (USP42) at 7p22 and runt-related transcription factor 1 (RUNX1) at 21q22 have been reported as recurrent, semi-cryptic aberrations in AML. AML is associated with 5q abnormalities and hyperploidy [1,2,3,4,5,6,7]. In terms of t(6;7), this abnormality was reported in three AML cases as a mainline abnormality included in complex chromosomal abnormality [8,9,10]. We report here a case of AML with a solitary t(6;7)(p21.3;p22) passenger translocation that developed at relapse after allogeneic hematopoietic stem cell transplantation (HSCT) in a patient with a normal karyotype at the initial diagnosis.

blood research

The first case of acute myeloid leukemia with solitary t(6;7)(p21.3;p22) passenger translocation that developed at relapse after allogeneic hematopoietic stem cell transplantation in a patient with a normal karyotype at the initial diagnosis