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Giant-cell tumor is predominantly a benign condition, but it can evolve into a malignant tumor or metastasize to the lung. Transformation of benign giant-cell tumor into sarcoma is relatively common after radiation therapy. We report here a case of a patient who had local recurrence seven years after marginal resection and radiation therapy for a giant-cell tumor of the sacrum. One years after initial operation, the patient returned to us because of a lump in the lower abdomen, and re-resection of the tumor and radiation therapy (50Gy) were performed. Microscopic examination showed the typical feature of benign giant-cell tumor. Seven years after the radiation therapy, low back pain developed gradually and a computerized tomography showed a huge tumor of the pelvic space. Histological features of the tumor indicated malignant transformation into fibrosarcoma.

Recurrence of Giant-Cell Tumor of Sacrum with Malignant Change after Radiation Therapy.