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Drugs included in new-quinolone are used for the treatment of leprosy with single lesion. These drugs are also known to be effective drugs for the treatment of multi-drug resistant M. tuberculosis. Recent emergence of new-quinolone resistant M. leprae and M. tuberculosis enforced the urgent elucidation of the mode of emergence of new-quinolone resistant strains. In this review, new-quinolone drugs, their mode of action and mechanism of acquisition of resistance by M. leprae and M. tuberculosis were explained. And rapid differentiation methods for resistant bacilli were also introduced.

nihon hansenbyou gakkai zasshi/nihon hansenbyō gakkai zasshi

Molecular mechanism of the acquisition of new-quinolone resistance in &lt;i&gt;Mycobacterium leprae&lt;/i&gt; and &lt;i&gt;M. tuberculosis&lt;/i&gt; and rapid differentiation methods for resistant bacilli