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The lipophilic yeasts Malassezia spp. are normally resident on the surface of the human body, and often associated with various skin diseases. Of the 18 known Malassezia spp., Malassezia restricta is the most predominantly identified Malassezia sp. found on the human skin. Malassezia possesses a large number of genes encoding lipases to degrade human sebum triglycerides into fatty acids, which are required not only for their growth, but also trigger skin diseases. Previously, we have shown tha MrLIP5 (MRET_0930), one of the 12 lipase genes in the genome of M. restricta , and is the most frequently expressed lipase gene in the scalp of patients with dandruff.

pH-Dependent Expression, Stability, and Activity of Malassezia restricta MrLip5 Lipase