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In spite of progress in researches in exercise and medicine area, still several contradictions exist regarding the real risk and benefit of use resistance exercise, mainly the high-intensity, for hypertension in what plays their metabolic variables. This way, objective of this dissertation was to analyze the influence of a high-intensity training program on the glucose, protein, lipids and hormonal metabolism of spontaneously hypertensive rats. For that we used male of lineage of spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY), with 20 weeks of life. The animals were divided in four groups: Sedentary SHR (SHRS); Trained SHR (SHRT); Sedentary WKY (WKYS); Trained WKY (WKYT). The high intensity training constituted of jumps in the water, in individual tanks, wearing a jacket coupled to the thorax containing a lead overload equivalent to 50% of the body mass. Four series of 10 jumps were accomplished, with an interval of 1 minute among each series, five days a week, during eight consecutive weeks. After the end of exercise training the animals went by the glucose tolerance tests and insulin tolerance test, and after this period all animals were killed and serum collected, through the blood collected directly of heart, it trims the glucose, triglycerides, total cholesterol, HLD and LDL cholesterol, total proteins, albumin and creatine kinase (CK) and CK-MB, insulin and IGF-1, GH and free fat acids (FFA). Samples of muscle gastrocnemius, white and red portions, soleus, liver and heart were collected and used for glycogen content, protein and DNA. In the hepatic and heart samples were still collected for analysis of IGF-1 and triglycerides. The supra-renal glands were removed for evaluation levels of total cholesterol through method enzymatic colorimeter. In the soleus muscle they were removed sliced for analyses synthesis and degradation for muscle, both incubated in half appropriate. The lineage of SHR animals presents important metabolic alterations as glucose intolerance, hyperinsulinemia, dyslipidemia, increase of enzymes CK and CK-MB. The highintensity exercise training improved the insulin sensibility, increased production of liver IGF1, decrease concentrations of heart IGF-1, decreased rate proteins/DNA of heart, improving the skeletal metabolism and heart muscle, however it didn't revert the dyslipidemia.

Influência do treinamento físico de alta intensidade sobre o metabolismo de ratos espontaneamente hipertensos (SHR)