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Colon cancer, which is considered to be a cancer of the elderly, may be influenced by dietary programming occurring during development. We examin ed the effects of a Western Style Diet (WD), high in fat (corn oil) (20%) and low in micronutrients [i.e.; folic acid (1 mg/g), choline (0.12%) and fiber (2%)] during pregnancy, l actation and post-weaning in order to examine the susceptibility to development of colon carcinogenesis induced by 1,2dimetylhydrazine (DMH) in male Sprague-Dawley (SD) rats. We evaluated whether WD reintroduction during adulthood can modify colon ca rcinogenesis susceptibility. WD was started at 12 days of pregnancy. F1 male pups were aned (21d) and fed the WD until postweaning (42d). Subsequently, they received a contro l diet (AIN-76A) until 70 days of age. At this point, they were given four subcutaneous injec tions of carcinogen DMH (40 mg/body weight). One group was reintroduced to WD during ad ulthood. Both the groups, fed on WD or control diet, were euthanazied at the end of the 20 week (medium-term assay) and ACF (aberrant crypt foci) were stereoscopically and his tologically scored for number, distribution and multiplicity along the colon. Maternal and post -weaning WD exposure decreased the susceptibility to development of ACF induced by DMH in the group with WD reintroduction during adulthood, which demonstrates WD reintroduct ion during adulthood recovers adaptative response programmed during fetal develop ment by preparing the organism for its likely adult environment . These findings indicate that maternal and post-wean ing WD exposure modifies the susceptibility to development of ACF induced by DMH in F1 male Sprague-Dawley pups. Key-words: fetal programming, thrifty phenotype, we stern diet, colon cancer, aberrant crypt foci (ACF).

Exposição à dieta ocidental durante a gestação, lactação, fase juvenil e susceptibilidade à carcinogênese química do cólon em ratos adultos da linhagem Sprague-Dawley