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Jugular thrombophlebitis is a major vascular disease in horses which can lead to head edema, decreased athletic performance and even death. Heparin is used for the treatment of this disease in order to minimize the development of thrombus. The aim of this experiment was to evaluate clinical, laboratory, ultrasound and venographic changes caused by administration of heparin in the treatment of experimental thrombophlebitis in horses. Ten horses were subjected to induction of unilateral jugular thrombophlebitis. The animals were divided into control group and the treated group, composed of five animals each that received during 10 days the administration of heparin. Prior to the induction of thrombophlebitis and daily after the establishment of the same physical examinations and ultrasound were performed until the 18th day. The laboratory tests activated partial thromboplastin (APTT), prothrombin time (PT) and total count platelet were determined the day before the induction of thrombophlebitis, during the induction period and measured daily until the 12th day post-induction. Red blood cells counts were performed in the preinduction, immediately after surgery for the induction of thrombus in the 3rd, 7th and 10th day after induced thrombophlebitis. Daily measurements of the length of the thrombi were subjected to statistical comparison with analysis of variance. Venographs were performed in the pre-induction, immediately before induction, after induction and every six days until the 18th day. In the control group, the thrombi to grow until the 9th day post-induction, when we observed a shortening of the thrombi and increased lateral flow. In the group treated with heparin there was a break in the growth of the thrombus after the start of administration of the drug and decrease in length of the thrombus with the appearance of flow down the sides of the cranial portion of the thrombus from the 6th day post-induction. However, after discontinuation of heparin was observed daily fast growth of the thrombus and decreased blood flow to the side. At the 18th day post-induction, all animals showed thrombus aspect hyperechoic and heterogeneous and intense flow to the side. Venographic examinations in both groups show an increase of compensatory vascularization, with visualization of collateral vessels draining the contrast from the cranial to the thrombus. Compensatory vascularization appeared to decrease with increase in the flow to the side of the thrombus. After the initial administration of heparin, the determination of APTT of animals belonging to the treated group showed

Avaliação da tromboflebite jugular experimental em equinos tratados com heparina