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Consequently, manytypes of natural or unnatural dioxopyrrolidinone and itsmodification have been successfully reported. Severalexperimental protocol have been successfully demonstratedon the preparation and exploration of 2,3-dioxo-4-car-boxy-5-substituted-pyrrolidines. Some examples includedecarboxylation reaction, bipiridines synthesis, oxidativecleavage for β-lactone synthesis and conversion of the2,3-dioxopyrrolidine to enamine using amino-dehydrox-ylating agent of potassium cyanate.

Diastereoselective Reduction of 2,3-Dioxo-4-carboxy-5-substituted Pyrrolidines Using NaBH4/AcOH and Heterogenous Hydrogenation Reactions

Diastereoselective Reduction of 2,3-Dioxo-4-carboxy-5-substituted Pyrrolidines Using NaBH₄/AcOH and Heterogenous Hydrogenation Reactions