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(diabete)                /                  .            . ,    (Meglitinide) (Mitiglinide, 1, KAD-1229, calciumbis[(2S)-4-[(3aR,7aS)-octahydro-2H–isoindol-2-yl]-4-oxo-2-benzylbutanoate]dihydrate)( Fig. 1)     2004               1,2.        .                   .            ,

Asymmetric Synthesis of Dimethyl 2-(S)-Benzylsuccinate, a Key Intermediate of Mitiglinide for Antidiabetes