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Organic Chemistry Division, School of Chemical Sciences, Kannur University Payannur Campus, India(Received November 27, 2012; Accepted April 9, 2013)ABSTRACT. A modified synthetic approach to the synthesis of heterocyclic food mutagens, 2-amino-1-methyl-6-phenylimi-dazo[4,5-b]pyridine (PHIP) and 2-amino-1,6-dimethylimidazo[4,5-b]pyridine (DMIP) is reported. This route highlights an optimizedpalladium catalysed Buchwald cross-coupling of 2-halo-1-methyl-imidazo[4,5-b]pyridine with benzophenoneimine followedby acidic hydrolysis to yield compound 7. Using finely tailored conditions, Suzuki cross-coupling reactions with highly efficient cat-alytic systems were performed as the final step on 8 to introduce the aryl group and methyl group on the heterocyclic core.Key words: Buchwald coupling, Imidazopyridine, Suzuki coupling, Heterocyclic amines

Cross-Coupling Reaction of 2-halo1-methyl-1H-imidazo[4,5-b]pyridine Offers a New Synthetic Route to Mutagenic Heterocyclic Amine-PHIP and DMIP