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Division of Nephrology, Samsung Medical Center, Sungkyunkwan University of School of Medicine, Seoul 135-710, KoreaReceived December 24, 2013, Accepted January 6, 2014Expanded polytetrafluoroethylene (ePTFE) grafts have been used as vascular access for many patientssuffering from end stage renal disease. However, the vascular graft can cause significant clinical problems suchas stenosis or thrombosis. For this reason, many studies have been performed to make drug eluting graft, butinitial burst is major problem in almost drug eluting systems. Therefore we used biodegradable polymer toreduce initial burst and make sustained drug delivery. The ePTFE grafts were dipped into a paclitaxel-dissolvedsolution and then PLGA-dissolved solution was passed through the lumen of ePTFE. We analyzed whether thedose of paclitaxel is enough and the loading amount of PLGA on ePTFE graft increases according to the coatingsolution’s concentration. Scanning electron microscope (SEM) images of various concentration of PLGAshowed that the porous surface of graft was more packed with PLGA by tetrahydrofuran solution dissolvedPLGA. In addition, in vitro release profiles of Ptx-PLGA graft demonstrated that early burst was graduallydecreased as increasing the concentration of PLGA. These results suggest that PLGA coating of Ptx loadedgraft can retard drug release, it is useful tool to control drug release of medical devices.Key Words : Hemodialysis, Vascular access, ePTFE graft, Paclitaxel, Biodegradable polymerIntroductionMany patients suffering from end stage renal diseaseusually receive hemodialysis three times a week. To performthe hemodialysis, the secure of vascular access is important.Most common forms of vascular access are the nativearteriovenous fistulas (AVF) and arteriovenous graft (AVG)using expanded polytetrafluoroethylene (ePTFE) graft.

New Coating Method for Sustained Drug Release: Surface Modification of ePTFE Grafts by inner coating PLGA