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Targeted Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk 363-883, KoreaReceived June 5, 2014, Accepted June 30, 2014Key Words : Gynostemma pentaphyllum , PTP1B, Dammarane-type triterpeneGynostemma pentaphyllum (Thunb.) Makino (Cucurbi-taceae), a perennial liana herb, is widely cultivated in China,Japan and Korea. It has been traditionally used as medicinalherbs for treatment of cardiovascular disease, hyperlipidaemia,hypertension, hepatitis, diabetes and cancer,

A New Dammarane-type Triterpene with PTP1B Inhibitory Activity from Gynostemma pentaphyllum