English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Wedescribe herein the enantioselective synthesis of C3-C8fragment of amphidinolide O (1).Retrosynthetic analysis was described in Figure 1. Amphi-dinolide O (1) might be assembled from two intermediates 2and 3 via esterification and ring closing metathesis as keysteps. Intermediate 4, a precursor to 3 as well as the targetmolecule in this paper, involves the γ,δ-unsaturated estermoiety along with α,β-chiral substituents with anti-stereo-chemical relationship. Those structural features could beavailable by Ireland-Claisen rearrangement of the corre-sponding (E)-enolate derived from the propionate ester 5.The ester 5 was prepared from the commercially available

Toward the Total Synthesis of Amphidinolide O: An Enantioselective Synthesis of C3-C8 Fragment