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Young Ho SeoCollege of Pharmacy, Keimyung University, Daegu 704-701, Korea. E-mail: seoyho@kmu.ac.krReceived March 13, 2013, Accepted April 10, 2013Key Words : Licochalcone A, Hsp90, Gefitinib resistance, Natural product, CancerThe epidermal growth factor receptor (EGFR), or ERBBfamily regulates essential cellular processes, including pro-liferation, survival, migration, and differentiation, and appearto play an important role in the etiology and progression oftumors.

Discovery of Licochalcone A as a Natural Product Inhibitor of Hsp90 and Its Effect on Gefitinib Resistance in Non-Small Cell Lung Cancer (NSCLC)