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Our results and those of previous studiesshow that the relationship between structural modificationand biological properties, strongly depends on the identity ofthe functional groups attached to the feruloyl structure. Among the useful biological properties of curcumin, theinhibitory property against adipocyte proliferation and differ-entiation has received significant attention because theseprocesses are critical in the development of obesity, which isa main cause of chronic diseases such as type II diabetes andcardiovascular disease.

bulletin of the korean chemical society

Synthesis of Curcumin Mimics Library with α,β-Unsaturated Carbonyl Aromatic Group and their Inhibitory Effect against Adipocyte Differentiation of 3T3-L1