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Department of Microbiology and the Brain Korea 21 Project for the Medical Sciences, Yonsei University College of Medicine, Seoul 120-752, KoreaReceived January 25, 2012, Accepted January 30, 2012Novel antibacterial oxazolidinones bearing pyrrolidinone ring system at the C-5 side chain were synthesizedand their in vitro antibacterial activities were evaluated. Most of the synthesized oxazolidinones showed goodantibacterial activity against the Gram-positive and Gram-negative bacteria tested.Key Words : Pyrrolidinone, Oxazolidinone, Antimicrobial activityIntroductionBecause of deficiency in innovative advance in the anti-bacterial drug development, the increasing incidence andprevalence of bacterial resistance to clinically useful anti-biotics is one of the most serious global health threats of thelast two decades.

Synthesis and Antibacterial Activity of Novel 2-Oxo-pyrrolidinyl Oxazolidinones