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E-mail: chenyan91030@yahoo.comReceived November 30, 2011, Accepted December 14, 2011In present study, CdSe quantum dots (QDs) were prepared with a novel but simple, effective and exercisablemethod. Nine different types of carbohydrate molecules were used to modify CdSe QDs. D-mannose (Man)-coated quantum dots were prepared for labeling human hepatoma (HepG2) cells, because of the highexpression of mannose receptor (MR) on HepG2 cells. The uptake characteristics of CdSe QDs-Man wereinvestigated in HepG2 cells. The absorption rate result of MTT assay in 48 h suggested the extremely lowcytotoxicity of CdSe QDs-Man. The presence of quantum dots was confirmed with fluorescence microscopy.These results were encouraging regarding the application of QDs molecules for early detection of HepG2 cells.Key Words : CdSe quantum dots, Carbohydrates molecules, HepG2 mannose receptor, Receptor-mediated en-docytosisIntroductionOne of the fundamental goals in biology is to understandthe complex spatio-temporal interplay of biomolecules fromthe cellular to the integrative level. To study these inter-actions, researchers commonly use fluorescent labeling forboth in vivo cellular imaging and in vitro assay detection.

Preparation of CdSe QDs-carbohydrate Conjugation and its Application for HepG2 Cells Labeling