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Department of Biology, Changwon National University, Changwon 641-773, KoreaReceived May 7, 2012, Accepted July 2, 2012New silver nanoparticle (AgNP)-loaded amino acid based hydrogels were synthesized successfully from poly(vinyl alcohol) (PVA) and poly(acryl amide- co-acryloyl phenyl alanine) (PAA) by redox polymerization. Theformation of AgNP in hydrogels was confirmed by using a UV-Vis spectrophotometer and XRD. The structureand morphology of silver nanocomposite hydrogels were studied by using a scanning electron microscopy(SEM), which demonstrated scattered nanoparticles, ca. 10-20 nm. Thermogravimetric analysis revealed largedifferences of weight loss ( i.e., 48%) between the prestine hydrogel and silver nanocomposite. The antibacterialstudies of AgNP-loaded PAA (Ag-PAA) hydrogels was evaluated against Escherichia coli (Gram-negative)and Staphylococcus aureus (Gram-positive) bacteria. These Ag-PAA hydrogels showed significant activitiesagainst all the test bacteria. Newly developed hydrogels could be used for medical applications, such asartificial burn dressings. Key Words : Nanocomposite hydrogels, Poly(acryl amide-co-acryloyl phenyl alanine), Silver nanoparticles,Anti-bacterial studyIntroductionSince hydrogels possess hydrophilic character and havepotential for biocompatibility, they have been of greatinterest to biomaterial scientists for many years.

Fabrication of Amino Acid Based Silver Nanocomposite Hydrogels from PVA- Poly(Acrylamide-co-Acryloyl phenylalanine) and Their Antimicrobial Studies