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Department of Graphic Arts Media, Shingu College, Seongnam 462-743, KoreaReceived March 23, 2011, Accepted April 5, 2011Key Words : Diels-Alder reaction, Oxazaborolidinium catalyst, Furan, Shikimic acid, TamifluTamiflu, a neuraminidase inhibitor, is an antiviral medica-tion used to treat influenza virus in patients who have hadsymptoms for less than 2 days. The current key startingmaterial for the production of Tamiflu is (-)-shikimic acid(1).

Highly Efficient Synthesis of (-)-Shikimic Acid from a Chiral Diels-Alder Adduct between Furan and Acrylate