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E-mail: hongjh@chosun.ac.krReceived January 18, 2011, Accepted February 21, 2011Steric and electronic parameters of 4'-substituents play significant roles in steering the conformation ofnucleoside analogues. In order to investigate the relationship of 4'-substituent with antiviral enhancement,novel 4'-phenyl-5'-norcarbocyclic adenosine phosphonic acid analogues were racemically synthesized via denovo acyclic stereoselective route from propionaldehyde 5. The phenyl substituted cyclopentenols 15a and 15bas key intermediates were successfully constructed via reiterative carbonyl addition of Grignard reagents andring-closing metathesis of corresponding divinyl 14. The synthesized nucleoside phosphonic acids analogues19, 20, 21, and 23 were subjected to antiviral screening against HIV-1. Key Words : Anti-HIV agent, 4'-Branched nucleoside, 5'-Norcarbocyclic nucleoside phosphonic acidIntroductionThe development of new effective antiviral agent is essen-tial for overcoming viral diseases, such as acquired immuno-deficiency syndrome (AIDS) caused by human immuno-deficiency virus (HIV). Recently, several branched nucleo-sides

Synthesis and Some Properties of 4'-Phenyl-5'-Norcarbocyclic Adenosine Phosphonic Acid Analogues