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(bpy is 2,2'-bipyridine and Hex-dtc ishexyldithiocarbamato ligands) were synthesized and characterized by elemental analysis and spectroscopicstudies. The cytotoxicity assay of the complexes has been performed on chronic myelogenous leukemia cellline, K562, at micromolar concentration. Both complexes showed cytotoxic activity far better than that ofcisplatin under the same experimental conditions. The binding parameters of the complexes with calf thymusDNA (CT-DNA) was investigated using UV-visible and fluorescence techniques. They show the ability ofcooperatively intercalating in CT-DNA. Gel filtration studies demonstrated that platinum complex could cleavethe DNA. In the interaction studies between the Pd(II) and Pt(II) complexes with CT-DNA, several binding andthermodynamic parameters have been determined, which may provide deeper insights into the mechanism ofaction of these types of complexes with nucleic acids.Key Words : DNA binding and thermodynamic parameters, Anti-tumor activity, Pd(II) and Pt(II) complexesIntroductionDeoxyribonucleic acid (DNA) is the primary target mole-cule for most anticancer and antiviral therapies according tocell biology.

DNA-Binding and Thermodynamic Parameters, Structure and Cytotoxicity of Newly Designed Platinum(II) and Palladium(II) Anti-Tumor Complexes