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Preorganization of synthetic receptor has recently received much attention in the molecular recognition research fields. As a model system for mimicry of biological events in relation to specific substrate recognition, various synthetic receptors based on calix[4]arene, resorcin[4]arene and foldamer structures have been extensively employed for the research of molecular recognition, presenting strong complex formation for specific guests including anionic species and biomolecules. In particular, water-soluble receptor attracts much attention in the molecular recognition, since significant biological events are mediated or triggered by specific substrate-receptor recognition in the aqueous media and it is very important to develop a preorganized structure of proteins for understanding the selective protein-substrate binding behaviors at the molecular level. The concept of preorganization is very crucial in the design and synthesis of artificial receptor, stabilizing substrate-receptor complex as well as the structure of receptor. Preorganization of artificial receptors has been produced via covalent synthetic methods and noncovalent interactions including hydrogen bonding and metal coordination. Previously, we have reported the preparation of water soluble receptor based on resorcin[4]arene, which was preorganized through intramolecular Pd complexation in water and thus showed more than ten times enhanced affinities for proper anionic guests in H NMR titrations. Herein we present molecular recognition of the isomerically preorganized receptors in aqueous media, which are inspired

Pd(II) Metal Coordination-driven Isomerically Preorganized Receptors with the Enhanced Affinity for Aromatic Carboxylates in Water