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Scheme 1. Synthesis of compound 1. Sensors based on the ion-induced changes in fluorescence appear to be particularly attractive due to the simplicity and high detection limit of the fluorescence. 1 Especially, a few rhodamine B derivatives have also been used as fluorescent chemosensors for metal ions, in which the spirolactam (nonfluorescent) to ring opened amide (fluorescent) process was utilized.

Rhodamine Derivative Bearing Histidine Binding Site as a Fluorescent Chemosensor for Hg2+

Rhodamine Derivative Bearing Histidine Binding Site as a Fluorescent Chemosensor for Hg²⁺