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Chemotherapy is a crucial anticancer strategy. Numerous compounds have been developed as potential candidates for anticancer drug, and many of these compounds, including FDAapproved anti-cancer drugs such as doxorubicin, daunorubicin and amsacrine, are known to reversibly interact with DNA to form drug/DNA complexes. 1 Large libraries of compounds of DNA-binding molecules have been synthesized by combinatorial chemistry. 2 However, the selection of viable candidates among the many compounds contained in these libraries is one of the major bottlenecks in drug discovery. 3 To overcome this problem, high-throughput screening (HTS) methods are used to screen large libraries of potential drug candidates for biological activity. 4 Generally, the anticancer drug’s biological activity is correlated with its binding affinities to DNA. 5 In the past, typical screening processes have included mass spectroscopy, nuclear magnetic resonance, light scattering, and electrochemistry. 6 Un

A Simplified Assay Method for Determining the Binding Affinities of DNA Binding Molecules to Duplex DNA