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These examples clearly demonstrate the remarkable potential of 1,4-DHPs as a source of valuable drug candidate.Owing to the wide range of biological and medicinal acti-vities, the synthesis of such compounds has become an impor-tant target in recent years. In 1882, Arthur Hantzsch reported first synthesis of substituted 1,4-dihydropyridines by one-pot condensation of ethylacetoacetate, aromatic aldehydes and ammonia. The reaction was conducted in acetic acid or at reflux in ethanol

Scolecite Catalyzed Facile and Efficient Synthesis of Polyhydroquinoline Derivatives through Hantzsch Multi-component Condensation