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A short and highly efficient synthetic method to prepare synthetically useful tetrahydroindolizinone derivatives from the ring-closing metathesis of N-allyl-5-allyl-5-hydroxylactams is described.

Cyclization of N-Allyl-5-allyl-5-hydroxylactams to 8a-Hydroxy-1,5,8,8a-tetrahydro-2H-indolizin-3-ones Using Grubbs' Catalyst