English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Enantiopure β-amino acids are crucial structural features of numerous biologically active natural products as well as important building blocks for the synthesis of β-peptides and β-lactam antibiotics. Numbers of stoichiometric chiral auxilaries and catalytic methods have been developed to make chiral β-amino acids. One of the most promising processes for the convenient preparation of chiral β-amino acids on large scale is the asymmetric hydrogenation of suitable unsaturated precursors such as β-acetamido acrylates with Rh(I) catalysts bearing chiral phosphine ligands. The requisite prochiral substrates are easily available by treatment of β-keto carboxylates with NH4OAc and subsequent acylation. However, while literally thousands of reports are concerned with the Rh-catalyzed enantioselective hydrogenation of related prochiral α-acetamido acrylates, only a few devoted to the hydrogenation of β-analogues as substrates exist. The main reason for this is probably different behavior in the asymmetric hydrogenation, which had for a long time been attributed to particular substrates such as the isomeric ethyl 3-acetoamido butenoates (E)-1 and (Z)-1.

bulletin of the korean chemical society

Enantioselective Hydrogenation of (E)-and (Z)-Isomeric Ethyl 3-Acetamidobutenoates with Rh-Bisphosphine Complexes: Effects of Substrate Geometry and Solvents on Reaction Rates and Catalyst Reusability