English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

reduced amide bond ψ(CH2NH) was introduced by the reductive alkylation of the preformed Fmoc-protected amino aldehyde with the free amino terminal of the resin bound peptide, in the presence of an excess NaBH3CN (1.0 M solution in tetrahydrofuran) in 1% acetic acid in N,Ndimethylformamide (DMF). 8 Cleavage and deprotection were achieved by treatment with a mixture of trifluoroacetic acid (TFA)/H2O/thioanisole (9/0.5/0.5, v/v/v) at room temperature for 8-9 h. The pseudopeptides (MM4 and MM5) containing unnatural amino acid were synthesized in solid phase synthesis described in Scheme 1. FmocLys(Boc)-OH was assembled on MBHA resin and then the Fmoc protection group of the amino acid bound on resin 1 was replaced by Cbz protection group. Deprotection of Boc group of the resin bound amino acid and then Fmoc amino acid coupling and deprotection in solid phase synthesis provided 3. The reduced amide bond ψ(CH2NH) was introduced by the reductive alkylation of the preformed Fmoc-protected amino aldehyde with the free amino terminal of the resin bound peptide 3, in the presence of an excess NaBH3CN (1.0 M solution in tetrahydrofuran) in 1% acetic acid in N,N-dimethylformamide (DMF). 8 Cleavage and deprotection achieved by treatment with a mixture of TMSBr/EDT/m-cresol/thioanisole/TFA (1.32/0.5/0.1/1.17/ 7.5, v/v/v/v/v) at 4 o C for 12 h provided the crude pseudopeptide. The crude peptide and pseudopeptide were purified by preparative HPLC. The yields of each product were over 40% and the products were obtained in high purity (generally > 95% by RP analytical HPLC, UV214 nm). The success of synthesis of peptides and pseudopeptides was confirmed by ESI mass. The prediction of in vivo peptide pharmacokinetics is quite difficult because there are many factors that determine peptide fate, including absorption rate, first-pass metabolism, hepatic and renal clearance, cellular binding and uptake, and circulating peptidase. 9 In vivo peptide stability in blood can be gauged by determining the in vitro stability in serum. 9 Thus, the half-life of the peptides and its pseudo

bulletin of the korean chemical society

Design and Synthesis of Antibacterial Pseudopeptides with a Potent Antibacterial Activity and More Improved Stability from a Short Cationic Antibacterial Peptide