English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

O-(3-[ 1 8 F]Fluoropropyl)-L-tyrosine (L-[ 1 8 F]FAT) was synthesized by nucleophilic radiofluorination followed by acidic hydrolysis of protective groups and evaluated with 9 L tumor bearing rat. L-[ 1 8 F]FAT is an homologue of O-(2-[ 1 8 F]fluoroethyl)-L-tyrosine (L-[ 1 8 F]FET) which recently is studied as a tracer for tumor imaging using positron emission tomography (PET). [ 1 8 F]FPT was directly prepared from the precursor of O-(3-p-toluenesulfonyloxypropyl)-N-(tert-butoxycarbonyl)-L-tyrosine methyl ester. FPT-PET image was obtained at 60 min in 9 L tumor bearing rats. The radiochemical yield of [ 1 8 F]FPT was 40-45% (decay corrected) and the radiochemical purity was more than 95% after HPLC purification. The total time elapsed for the synthesis of [ 1 8 F]FPT was 100 min from EOB (End-of-bombardment). A comparison of uptake studies between [ 1 8 F]FPT and [ 1 8 F]FET was performed. In biodistribution, [ 1 8 F]FPT showed similar pattern with [ 1 8 F]FET in various tissues, but [ 1 8 F]FPT showed low uptake in brain. Furthermore, [ 1 8 F]FPT showed higher tumor-to-brain ratio than [ 1 8 F]FET. In conclusion, [ 1 8 F]FPT seems to be more useful amino acid tracer than [ 1 8 F]FET for brain tumors imaging with PET.

Synthesis of O-(3-[18F]Fluoropropyl)-L-tyrosine (L-[18F]FPT) and Its Biological Evaluation in 9L Tumor Bearing Rat

Synthesis of O-(3-[¹⁸F]Fluoropropyl)-L-tyrosine (L-[¹⁸F]FPT) and Its Biological Evaluation in 9L Tumor Bearing Rat