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and Sung Hye ShinDepartment of Chemistry, Hallym University, Chunchon, Kangwondo 700-201, KoreaReceived February 23, 2004Key Words : Asymmetric reduction, Oxazaborolidine-catalyzed reduction, Chiral drugs, Chiral 2-N-Boc-amino-1-arylethanols, (S)-CBS-oxazaborolidineOptically active 2-amino-1-arylethanols are importantstructural elements in chiral drugs such as α- or β-adrenergicblockers and agonists in the treatment of cardiovasculardisease, cardiac failure, asthma and glaucoma.

bulletin of the korean chemical society

Efficient Synthesis of Optically Active 2-N-Boc (or Cbz)-amino-1-arylethanols as Key Intermediates for Synthesis of Chiral Drugs via Asymmetric Reduction