English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

In the course of our study to develop didentate ligands that might provide wide bite angles in the metal chelation, we observed that a P,O-chelation mode could intervene with expected P,N-chelation in the palladium catalyzed allylic alkylations with aminophosphane ligands 1. 1 The P,Ochelation mode was supported by the X-ray crystal structure of the P,O-chelated palladium complex 2 (PF6 - counterion). 2 Also, a moderate enantioselectivity was obtained with the ligand 3, which suggested that other aminophosphane ligands, depicted as a general structure 4, might be developed as efficient ligands for the catalytic reactions. While a number of hetero-chelates such as P,N-, P,O- and P,S -chelates 3,4 have been developed for the catalytic reactions, neutral P,O-chelates based on carboxamide functionality have been rarely studied for that purposes: Intervention of the P,O-chelation mode in the catalytic reactions from amido-phosphane moiety have been observed earlier; 5,6 however, use of P,O-chelates based on carboxamide oxygens for the catalytic reactions appeared very recently. 7 Chiral P,O-chelates of amido-phosphane derivatives can be readily synthesized from various known chiral amines and carboxyphosphanes. We synthesized amidophosphanes from simple chiral amines and evaluated their ligand ability in the catalytic reaction. 8 Our study demonstrates that simple amido-phosphanes constitute a potentially useful ligand system for the palladium-catalyzed allylic alkylations.

Amido-Phosphane Ligands as P,O-Chelates in Palladium-Catalyzed Enantioselective Allylic Alkylations