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It seems very interesting and also strange that a malignant disease can be treated with antibiotics and acid suppressant combination therapy, rather than chemotherapy or radiotherapy. Infectious agents such as hepatitis B virus and hepatitis C virus, Epstein-Barr virus, Helicobacter pylori, and herpes simplex virus are well known causative agents for chronic inflammation associated cancers including hepatocellular carcinoma, stomach cancer, and cervical cancer. Even though the very early event of carcinogenesis starts from the chronic persistent infection status, once established cancers must be treated with chemo- and radiotherapy. Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is the only exception from the rules. Gastric MALT lymphoma is a shortened name of extranodal marginal zone B cell lymphoma of mucosa associated lymphoid tissue of stomach and typically a low-grade malignancy. In addition to B cell monoclonality, this is characterized by a dense lymphoid infiltrate mainly composed of small-size lymphocytes that invade and destroy the gastric epithelium, configuring the lymphoepithelial lesion which is pathognomonic of MALT lymphoma diagnosis. 1 The discovery of the strong relationship between H. pylori infection and gastric MALT lymphoma naturally suggested H. pylori eradication to treat lymphoma. The effectiveness of eradication has been well accepted and both hematology and gastroenterology international guidelines currently advise H. pylori eradication as first-line therapy for gastric MALT lymphoma. 2-4

gut and liver

<i>Helicobacter pylori</i>Eradication Therapy, the Reasonable First Line Therapy for Gastric Mucosa-Associated Lymphoid Tissue Lymphoma Irrespective of Infection Status and Disease Stages

Helicobacter pyloriEradication Therapy, the Reasonable First Line Therapy for Gastric Mucosa-Associated Lymphoid Tissue Lymphoma Irrespective of Infection Status and Disease Stages