English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The frequency of esophageal cancer is globally on the increase. Esophageal cancer is a relatively rare type of cancer in Korea: its incidence and prevalence rates are 3.1 and 6.4, respectively, out of 100,000 persons. Esophageal squamous cell carcinoma (ESCC) has been regarded as a type of cancer with a poor survival rate and is characterized by the ninth highest mortality rate among all the types of cancer. As the early diagnosis using esophagogastroduodenoscopy and technological development, which involves image enhancement and endoscopy using iodine dye, make a larger number of esophageal cancer patients diagnosed early and as the development of therapeutic protocols improves the long-term survival rate, the prevalence of esophageal cancer is on the increase. As a result, secondary primary malignancy (SPM) in esophageal cancer patients has attracted attention and a few relevant studies were conducted.1–3 Esophageal cancer patients may often have SPM in the head and neck, stomach and rarely have it in the colon, the lungs, the kidneys, and the female breasts.1 SPM, which accompanies esophageal cancer, shares risk factors with the cancer. Risk factors for ESCC usually include smoking (ESCC, 3 to 7 fold; adenocarcinoma, 2 fold risk), excessive alcohol intake (≥3 drinks/day), diet, achalasia, and low socioeconomic status; of these, the first two seem to be significant risk factors.4 It is widely known that head and neck cancer, a typical type of SPM, shares major risk factors with ESCC and frequently accompanies it.5Esophageal cancer and colorectal neoplasm (CRN) also share some risk factors and colorectal cancer reportedly forms approximately 7% to 16% of all the types of SPM for esophageal cancer.2,6 While a few researchers have reported that Barrett’s metaplasia or esophageal adenocarcinoma patients are at higher risk of CRN, there are relatively fewer studies on the correlation between ESCC and CRN. The meta-analysis performed by Andrici et al.7 showed that Barrett’s metaplasia almost doubled the risk of colon polyp and colorectal cancer. Bollschweiler et al.,8 who conducted a case-control study in a total of 171 esophageal cancer patients (78 adenocarcinoma and 93 ESCC), found that ESCC was relatively less correlated with CRN than adenocarcinoma: the ESCC and adenocarcinoma groups showed approximately 2-fold and 4.35-fold higher prevalence of CRN, respectively, than the control group. In contrast, colonoscopic evaluation in ESCC patients, which was restrictively conducted, obtained conflicting results.8–11Recently, Baeg et al.12 performed retrospective analysis to determine correlation between ESCC and CRN. He compared 60 patients, who were recently diagnosed with ESCC and received colonoscopy within a year after the diagnosis, with 180 persons in the control group with age, gender, and body mass index matched. As a result, a significantly higher percentage of the ESCC group had CRNs (odds ratio [OR], 2.311; 95% confidence interval [CI], 1.265 to 4.220) or advanced CRNs (OR, 2.317; 95% CI, 1.185 to 4.530). Multivariate analysis showed that the significant risk factors for CRN and advanced CRN were ESCC (OR, 2.157; 95% CI, 1.106 to 4.070; p=0.024) and older age (OR, 1.068; 95% CI, 1.032 to 1.106; pu003c0.001). On the basis of these results, it is necessary to consider performing colonoscopy in case of ESCC diagnosis because ESCC patients may see a significant increase in the CRN and advanced CRN rates.Although this study found that smoking was not a potential risk factor for CRN, it was likely to act as a confounding factor because the ESCC group had a significantly higher proportion of patients with smoking history than the control group. Besides, as a retrospective study, it rarely provides accurate baseline information about significant risk factors for ESCC and colorectal cancer, such as smoking and alcohol intake. Multivariate analysis found no risk factor for CRN in the ESCC group. This is probably because it, as a single-center study, was conducted in a small sample. The CRN rate was ≥60% in the ESCC group and u003e40% in the control group; CRNs could have been overestimated in the former group since the adenoma detection rate is generally about 20% to 25%. It is therefore necessary to conduct multicenter, prospective research in a larger number of patients.Despite these limitations, colonoscopy is expected to be applicable right after diagnosis of esophageal cancer in clinical practice, as recommended on the basis of these results. Taking unfavorable prognoses of esophageal cancer into account, however, it is necessary to conduct a well-designed, randomized prospective study to see if this will improve prognoses for esophageal cancer patients in the long term and care should be taken to determine a specific group of patients and a specific clinical stage in which colonoscopic screening is useful.

Do Esophageal Squamous Cell Carcinoma Patients Have an Increased Risk of Coexisting Colorectal Neoplasms?