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A worldwide increase in amoxicillin resistance in Helicobacter pylori is having an adverse effect on eradication therapy. In this study, we investigated the mechanism of the amoxicillin resistance of H. pylori in terms of amino acid substitutions in penicillin-binding protein 1 (PBP1).

Substitutions in Penicillin-Binding Protein 1 in Amoxicillin-ResistantHelicobacter pyloriStrains Isolated from Korean Patients