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The notion that acute hepatitis A superimposed on chronic hepatitis B infection leads to a worse outcome than acute hepatitis A alone remains controversial. The aim of this study was to determine the influence of the presence of hepatitis B surface antigen (HBsAg) on the severity of acute hepatitis A.

Comparison of the Clinical Features of Hepatitis A between HBsAg-Positive and HBsAg-Negative Patients