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Ab s t r Ac t Background and objective: This study based on the antifertility action of Leonotis nepetifolia ethanol extract (whole plant) in the animal model male Wistar Albino rats. Leonotis nepetifolia is reported to have antioxidant activity, antiproliferative potential, hypotensive potential, antiinflammatory, antiplasmodial, antibacterial, antifungal, analgesic, anticancer, laxative and narcotic activities. The plant aids in the recovery of malaria, diarrhea, bronchial asthma, common cold, cough, and fever, particularly used during menstrual pain. Materials and methods: The animals were grouped into four with five rats each. Control group (group I) received normal saline. The other three groups of rats were treated with the specified dose (group II-100 mg/kg, group III-150 mg/kg, and group III-200 mg/kg) of Leonotis nepetifolia ethanolic extract for a period of 55 days. Results: A marked reduction in the weight of accessory sex organs/testis, sperm count, and sperm motility were observed in the treated groups. Serum hormonal levels and few biochemical parameters also showed variation compared to the control group. The reports revealed that the treated adult male rats had decreased the counts of female’s impregnation. Conclusion: Hence, this current research concluded that L. nepetifolia ethanolic extract (whole plant) repressed sperm motility, concentration, and the testosterone proving dose-dependent antifertility effect.

Antifertility and Antioxidant Activities of Ethanolic Extract of Leonotis nepetifolia in Male Albino Rats