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Ab s t r Ac t Introduction : Onset of type 2 diabetes mellitus (T2DM) at early age heralds many years of disease and an increased risk that the full range of both microvascular and macrovascular complications will occur when affected individuals are still relatively young. Thus, further generations may be burdened with morbidity and mortality at the height of their productivity, potentially affecting workface, and healthcare systems of countries across the world. Materials and methods: The present study carried out at Department of Biochemistry at tertiary care hospital; total 100 nondiabetic siblings and offspring of T2DM patients between the age group 20 and 50 years selected on outpatient department (OPD) basis and compared with 100 ageand sex-matched healthy controls. Serum tested for plasma glucose level, serum high-sensitivity C-reactive protein (hs-CRP), serum cholesterol, serum triglycerides (TGs), and high-density lipoprotein (HDL) levels. Results: The mean value of blood sugar level did not show significant difference between the cases and controls (92.02 ± 9.23 vs 91.77 ± 7.99, p ≥ 0.05). The mean values of hs-CRP (2.4 ± 1.98 vs 1.0 ± 0.38), TG (167.35 ± 17.35 vs 124.63 ± 13.55), total cholesterol (TC) (176.99 ± 12.45 vs 147.59 ± 9.72), low-density lipoprotein (LDL) (106.41 ± 12.99 vs 71.65 ± 11.24), and very high-density lipoprotein (VHDL) (33.47 ± 3.47 vs 24.93 ± 2.71) (all p < 0.001) were increased, however mean value of HDL (37.11 ± 3.99 vs 51.01 ± 3.93) was decreased in the cases as compared to controls. High-sensitivity C-reactive protein shows positive correlation with TG, TC, LDL, and very low-density lipoprotein and has negative correlation with HDL. Conclusion: Timely screening and early detection of the increased hs-CRP in the first-degree relatives of T2DM subjects may help clinicians enable to intervene early in the course of disease and to prevent further complications and outcomes. Therefore, primary prevention by target screening among high-risk individuals to prevent transition to overt T2DM by therapeutic lifestyle changes is a feasible and attractive alternative to reduce diabetes-related morbidity and mortality.

Evaluation of High-sensitivity C-reactive Protein and Lipid Profile in Nondiabetic Siblings and Offspring of Type 2 Diabetes Mellitus Patients