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Type 2 DM is a cluster of syndromes characterized by long-lasting hyperglycemia accompanied with disturbances of carbohydrate, fat and protein metabolism due to absolute’ and/or relative’ deficiency of insulin secretion’ and/or its action.’ Type 2 diabetes is a group of disease characterized by variable notches of insulin resistance’ and/or augmented glucose formation. Insulin resistance arises when the cells develop lesser sensitive to insulin effects.1 DM reasons for long time dysfunction of several organs like heart, kidneys, blood vessels and eyes. Much of this increased mortality and morbidity is due to cardiovascular complications in diabetic patients.2 Many studies have shown that diabetes is consistently accompanying with changes in blood lipids and lipoproteins, and these adaptations are of concern, because of their possible role in the etiology of the increased cardiovascular disease associated with diabetes.3-5 Among the various factors for developing increased cardiovascular risk in diabetes; the dyslipidemia is the major contributor. The common type of dyslipidemia in diabetes mellitus is considered by elevated triglycerides (TG), low levels of HDLc and an increased prevalence of small LDLc. There are two categories of cholinesterases based on biological properties: • Specific cholinesterase or acetylcholinesterase or true cholinesterase: It is found in the central and peripheral nervous system, muscles and erythrocytes. It is a high turnover enzyme with high affinity for acetylcholine, and with low affinity for non-choline esters.6 • Nonspecific or pseudo-cholinesterase or serum cholineesterase or butyryl-cholinesterase (BChE): The enzyme hydrolyzes both choline’ and aliphatic’ esters. Serum cholinesterase is alpha glycoprotein formed in the liver. Mainly distributed in the central and peripheral nervous system and also in the liver. It has a lesser affinity 1Tutor, 2Professor and HOD 1,2Department of Biochemistry, Shimoga Institute of Medical Sciences, Shimoga, Karnataka, India

Correlation of Serum Cholinesterase with Lipid Indices in Type 2 Diabetes Mellitus Patients in McGann Teaching Hospital, Shimoga, Karnataka, India