English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Down syndrome/Trisomy 21 is the most common chromosomal anomaly with an incidence of 1 in 800 live births, and it is also an added factor for growth retardation and intellectual disabilities.1 Down syndrome patients present with various birth defects. Down syndrome has an increased risk of developing endocrinal abnormalities, especially thyroid disorders. It consists of a constellation of clinical signs and symptoms and associated with various forms of thyroid dysfunction (congenital/acquired).2 Hypothyroidism accounts for about 28%.3 The additive effects of both comorbid conditions lead to further amplification of the clinical problems in these children, the symptoms of which are often mistaken for the natural course of the disease.3 The prevalence of hypothyroidism is more compared with hyperthyroidism. The prevalence of congenital hypothyroidism is 30 times more in newborn with Down syndrome than normal newborns.4 This is a treatable cause of mental retardation, thus early detection and treatment are essential in order to maximize cognitive abilities in this already impaired population.4

Thyroid Dysfunction and Its Influence in Growth Velocity in Children with Down Syndrome: A Retrospective Study