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Porphyria is a clinical condition that occurs due to a defect in heme synthesis. This condition may be genetic or acquired in nature.1 The signs and symptoms of patients suffering from porphyria usually overlap with other clinical conditions, thereby leading to misdiagnosis and inappropriate treatment in most patients. The diagnosis becomes even more challenging when a case of porphyria presents with an unusual presentation. Thus, most of the cases remain underreported due to misdiagnosis. Hence, the true prevalence of porphyria is not known. The literature search revealed that incidence of porphyria cutanea tarda is 40 new cases per 1 million people per year.2 The prevalence of acute intermittent porphyria in the general adult population ranges between 1 and 8 per lakh.3,4 An accurate and definite diagnosis of porphyria and its types can be made only when enzyme defect or mutation can be detected. However, the availability and cost of these tests is an important practical problem encountered in a country like India. In this article, we discuss a probable case of porphyria cutanea tarda/variegate porphyria based upon the clinical picture of patient. These cases can be easily confused with other skin diseases due to their presentation in the form of photosensitive lesions. Hence, we wish to propose a simpler diagnostic approach based on easily available facilities to diagnose patients with porphyria.

Ultraviolet Absorption Spectral Scan and Fluorescence Emission Spectral Scan Analysis: Potential Tests with Diagnostic Utility in Porphyria