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diagnosis of hypothyroidism and in the therapeutic aspect also. Vitamin D, being a hormone, acts on various types of cells and plays multiple roles. Other than bone metabolism, it has a causative role in various diseases2,3 like diabetes mellitus,4 cancer,5 multiple sclerosis,6 autoimmune diseases,7 and atherosclerosis.8 Vitamin D not only acts through the immune-mediated process but also acts on the thyroid follicular cells by inhibiting directly the thyrotropin-mediated stimulation of iodine uptake in dose-dependent manner.9 A population-based study has observed low thyroid-stimulating hormone (TSH) among younger individuals.10 Hence, the reliability of TSH in the diagnosis of hypothyroidism in younger individuals is affected. Thus, in the present study, the relation between TSH and vitamin D with triiodothyronine (T3) and thyroxine (T4) at the time of diagnosis of hypothyroid cases has been evaluated.

Reliable Earlier and Causative Biomarker in newly Diagnosed Hypothyroid Cases—Vitamin D: A Case–control Study