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Background: Rapid identification of fungi and molds reduce turnaround time and cost for diagnosis of infections with these organisms in a clinical microbiology laboratory. We report here the clinical evaluation of the VITEK mass spectrometry system for rapid fungal identification in comparison to the internal transcribed spacer (ITS) DNA polymorphism method. Methods: Total 136 archived isolates comprising 126 yeast and 10 molds were analyzed by mass spectrometry (VITEK system) and ITS sequencing for identification of fungi. Results: Majority of the yeast isolates belonged to genus Candida (N = 123), followed by one isolate each of Trichosporon, Cryptococcus, and Rhodotorula. Amongst molds, Aspergillus (N = 4), Trichophyton (N = 3), Fusarium (N = 2) and Rhizopus (N = 1) were identified. Overall, correct species-level identification was obtained in 135/136 (99.26%) isolates with a single isolate of Candida auris misidentified as Candida haemulonii by VITEK MS. Conclusion: The VITEK MS system, a matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDITOF MS) system, is a reliable and rapid method for the identification of most of the fungi. Further expansion of the database of the VITEK MS for emerging pathogens is needed to enhance its performance.

Evaluation of the VITEK Mass Spectrometry System for Rapid Identification of Medically Important Yeasts and Molds